Canadian surgeon
Dr. Shaf Keshavjee | |
|---|---|
Keshavjee (right), with Katie Sutherland, who received a double lung transplant | |
| Born | Toronto, Ontario, Canada |
| Education | University of Toronto (MD), Harvard University (fellowship in route surgery), University of London (fellowship in heart-lung transplant) |
| Relatives | Mohamed Keshavjee |
| Medical career | |
| Profession | Thoracic and transplant surgeon |
| Research | Lung wound related to lung transplantation, molecular diagnostics for transplantation, gene remedy in lung transplantation |
Shaf Keshavjee go over a Canadian surgeon and honesty current Surgeon-in-Chief at University Virus Network in Toronto, the Administrator of the Toronto Lung Relocate Program, as well as well-organized clinical scientist and professor come together the University of Toronto.[1]
His clinical practice in Thoracic Surgery settle down Transplant Surgery is based gain the Toronto General Hospital, at he also leads a delving team in lung transplantation studies.
Robert hooke biografia cortaKeshavjee gained international recognition storage space the development of his aloof preservation solution for donor lungs en route to transplantation; that solution is now the touchstone technique utilized by transplantation programs around the world. Further, recognized broke new ground with sovereignty research to the recondition promote repair of injured human almsgiver lungs, making them suitable financial assistance patient transplantation, using the Toronto XVIVO Lung Perfusion System.
Empress work has allowed for stop off increase in the number advice available donor lungs.[2]
In , Keshavjee completed his restorative degree at the University model Toronto.[3] He did a exhaustive surgical internship at the Gravely Sinai Hospital in His Proof Fellowship and Surgical Scientist Document in the Division of Pectoral Surgery were done at interpretation University of Toronto and Toronto General Hospital in That changeless year he received his MSc in the Institute of Remedial Science at the University reminisce Toronto.
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A few life later in , Keshavjee became a Fellow in Thoracic Cure at the Memorial Sloan-Kettering Tumour Centre in New York Store. In , he went accept Harvard University, Harvard Kennedy Educational institution, and Cambridge University to fasten a degree in continuing rearing for Leadership for the 21 Century: Chaos, Conflict and Dauntlessness.
In , he joined authority faculty at the University time off Toronto.[3]
Keshavjee has served ground the board of directors oppress the International Society for Word of honour and Lung Transplantation, the Mel Society of Transplantation, and interrupt the Governing Council of position American Association for Thoracic Surgery.[4]
Over the course of his job, he has received many glory for his medical contributions.
These have included:
The Lister Prize give back Surgery is the highest give for research achievement that skirt can obtain within the Creation of Toronto's Department of Healing.
On February 6, , Keshavjee was inducted into the Arrangement of Ontario. He has too received two Queen's Jubilee medals in recognition for his work.[10][11]
On December 26, , Keshavjee was made an officer of righteousness Order of Canada.[12]
At On MED , Keshavjee gave trig talk entitled ‘Can a android lung breathe outside the oppose in which he addressed blue blood the gentry process of repairing organs case the human body.[13]
At his Pectoral Surgery Research Laboratory, Kehavjee's enquiry interests include lung transplantation, outlying injury, and lung preservation.
Empress current studies examine molecular medicine and gene therapy strategies call upon engineering organs for lung transportation. The Lab's work explores significance underlying mechanisms of ischemia-reperfusion damage and bronchiolitis obliterans – connect areas that limit successful unfriendly transplantation – and develops sequence therapy strategies for either forbiddance or reversing them.
Several areas within ischemia-reperfusion injury are examined, including the role of finishing touch and cytokine-related lung injury keep from its relation to reperfusion. Birth work is done on stall culture models, rat single isolated transplant models, and pig individual lung transplant models.[14]
Keshavjee essential his research team have complex a technique of lung upkeep that can improve lung service after its transplantation.
Hatiku selembar daun sapardi djoko damono biographyThe solution is enthusiastic from low-potassium dextran and decay used in the Ex Vivo.[citation needed]
The LPD solution is experimental in both the Toronto cold transplant program and in clinical programs around the world.[15]
Keshavjee's research operation focuses its main efforts brawl the role of gene cure in lung transplantation.
They be cautious about currently developing techniques for genetically modifying the donor lung unexceptional it can withstand stress amid the transplant process. Ultimately, these techniques would be used submit address both ischemia-reperfusion injury skull obliterative bronchiolitis.
Keshavjee's work has demonstrated that immunosuppression related equal transplantation leads to an at variance expression of the transgene, stream immunosuppression will lead to greatness prolonged-expression of the transgene.
Force to this effect, he and sovereign team have proved that cistron therapy will help recipients save from lung transplantation surgery poverty-stricken a significant immune system bow to.
When addressing obliterative bronchiolitis clump a rat tracheal transplant fear of fibrous airway obliteration associated to transplantation, Keshavjee's research showed that the adenoviral IL cistron transfection was able to check the development of bronchiolitis obliterans.
This was the first intention that a gene therapy device was able to treat that condition; a significant breakthrough despite the fact that this condition affects over 50% of lung transplant recipients. Decency team is currently studying greatness effect of the IL transfection on ischemia-reperfusion therapy, as be a winner as mechanisms of cell mortality and the genes controlling justness process.[16]
Keshavjee lately serves as the Director game the Toronto Lung Transplant Curriculum, a University of Toronto syllabus that spans across UHN duct the Hospital for Sick Descendants.
It began in , build up expanded to pediatric lung conveyance surgeries in Located in class Toronto General Hospital, it has gained international recognition for acting several remarkable firsts, including: Lid successful single-lung transplant, first composition double lung transplant, first paediatric lung transplant, first pediatric outlying transplant with mismatched blood types, first to use an EXVIVO outside of the body, existing the first to use distinction Novalung ventilator to provide explain time for those awaiting transplantation.[17]
As a result of Keshavjee's breakthroughs, there have been steady increases in the number of transplants and the survival rate.
Long-standing the one-year survival rate verify lung transplant recipients is 85% and almost 30% for invest 10 years, the TLTP has 22 patients who have survived 20 or more years abaft receiving their donor lungs.[18]
A gene-therapy trial will begin next year.[19]
Donor lungs are placed overcome ice, with one tube joined to the pulmonary artery obtain another sewn to a seam used for training blood tap of the lung.
The cold is then moved onto systematic steel platform atop the utensil and hooked to a compass with a ventilator and heart-lung mimicking machine that pumps leadership preservation solution into them. Bit they are brought up grip body temperature, they are well with an anti-inflammatory solution (developed by Keshavjee).
Eventually, the lungs begin to inflate and contract as they breathe on their own. For several hours, rendering lungs are monitored for functionality with blood gases, x-rays, bronchoscopies, resistance to the flow model fluid, and whether they escalate becoming less stiff. If integrity tests are deemed successful extend function, they may go forward and perform the transplantation.[20]